CONDITION REFERENCE
Adiposis dolorosa
Information from MedlinePlus Genetics about this condition and how it can be inherited.
About this condition
Adiposis dolorosa is a condition that is characterized by painful fatty (adipose) tissue just underneath the skin (subcutaneous). The pain is often associated with multiple noncancerous (benign) tumors called lipomas. Adiposis dolorosa occurs most often in women between the ages of 35 and 50 who are overweight or have obesity.
Adiposis dolorosa affects the adipose tissue. Adipose tissue is found in many parts of the body. It stores fat for energy and provides support for the body’s structures. In some individuals, lipomas develop within the adipose tissue. These lipomas can occur anywhere on the body, but they are most often found on the torso, buttocks, or the upper arms and legs. The lipomas in people with adiposis dolorosa usually feel like firm bumps (nodules) underneath the skin and tend to be painful. The pain can be severe, particularly if the lipomas are pressing on a nearby nerve. In some people, the pain is disabling.
People with adiposis dolorosa may experience additional signs and symptoms. However, these features do not occur in all people with adiposis dolorosa, and it is unclear whether they are directly related to the condition. Researchers are working to learn more about the signs and symptoms of this condition.
Inheritance
- Autosomal dominant
A condition can have several forms with different inheritance patterns. Each pattern may apply to a different gene or form of the condition.
Related genes
The source data used here does not list individual genes. Some conditions involve changes to chromosomes or have other causes.
YOUR DNA FILE
What can your DNA file tell you?
Your DNA file only includes the positions your test checked and reported. Consumer DNA kits usually test selected positions. Sequencing files can also leave out positions that were not reported or where the test could not give a result.
A variant missing from your file does not mean you tested negative for it. A ClinVar classification applies to a particular variant and the condition or finding it was reported for. It does not apply to everyone with that gene. An uncertain finding cannot establish a diagnosis.
BioDecode reads supported DNA files on your computer. It cannot fill gaps in your test, diagnose a condition or replace clinical testing.
Sources and dates
The source information on this page last changed on 2026-09-18.
MedlinePlus Source details
Source release: Fri, 18 Sep 2026 05:17:13 GMT
Source publication: 2026-02-12
Source review: 2026-02
SHA-256: fdc8bd614310c12718379cef6569962e5d0e791cecabcc355b53a72816ac263a
About the library sources · Latest validated release · Record c8845177dd70