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Genetics Library / Conditions / Y chromosome infertility

CONDITION REFERENCE

Y chromosome infertility

Information from MedlinePlus Genetics about this condition and how it can be inherited.

About this condition

Y chromosome infertility is a condition that affects the production of sperm and causes male infertility, which means it is difficult or impossible for affected men to father children. An affected man's body may produce no mature sperm cells (azoospermia), fewer than the usual number of sperm cells (oligospermia), or sperm cells that are abnormally shaped or that do not move properly. Men with Y chromosome infertility do not have any other signs or symptoms related to the condition.

Some men with Y chromosome infertility who have mild to moderate oligospermia may eventually father a child naturally. Men with oligospermia may also be helped with assisted reproductive technologies; most men with Y chromosome infertility have some sperm cells in the testes that can be extracted for this purpose.

Source: MedlinePlus, National Library of Medicine. Source publication: 2024-09-19. Source review: 2018-12.

Inheritance

  • Y-linked
  • Not inherited

A condition can have several forms with different inheritance patterns. Each pattern may apply to a different gene or form of the condition.

Related genes

MedlinePlus lists these genes for this condition. Open a gene page to read any available ClinGen reviews and ClinVar records.

  • DAZ1deleted in azoospermia 1
  • RBMY1A1RNA binding motif protein Y-linked family 1 member A1
  • TSPY1testis specific protein Y-linked 1
  • KDM5Dlysine demethylase 5D
  • USP9Yubiquitin specific peptidase 9 Y-linked
  • DDX3YDEAD-box helicase 3 Y-linked
  • PRYPTPN13 like Y-linked
  • VCYvariable charge Y-linked
  • CDY1chromodomain Y-linked 1
  • DAZ3deleted in azoospermia 3
  • DAZ2deleted in azoospermia 2
  • DAZ4deleted in azoospermia 4
  • HSFY1heat shock transcription factor Y-linked 1
  • RPS4Y2ribosomal protein S4 Y-linked 2
  • HSFY2heat shock transcription factor Y-linked 2

YOUR DNA FILE

What can your DNA file tell you?

Your DNA file only includes the positions your test checked and reported. Consumer DNA kits usually test selected positions. Sequencing files can also leave out positions that were not reported or where the test could not give a result.

A variant missing from your file does not mean you tested negative for it. A ClinVar classification applies to a particular variant and the condition or finding it was reported for. It does not apply to everyone with that gene. An uncertain finding cannot establish a diagnosis.

BioDecode reads supported DNA files on your computer. It cannot fill gaps in your test, diagnose a condition or replace clinical testing.

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Sources and dates

The source information on this page last changed on 2026-09-18.

MedlinePlus Source details

Open source record ↗

Source release: Fri, 18 Sep 2026 05:17:13 GMT
Source publication: 2024-09-19
Source review: 2018-12

SHA-256: fdc8bd614310c12718379cef6569962e5d0e791cecabcc355b53a72816ac263a

About the library sources · Latest validated release · Record 1567ecbf0a9b