GENE REFERENCE / HGNC:12307

TRIP13

thyroid hormone receptor interactor 13

protein-coding gene5p15.33Gene information

What does this gene do?

The TRIP13 gene provides instructions for making a protein that has several roles in cell division. One important role is to help ensure proper chromosome separation when cells divide. Before cells divide, they must copy all of their chromosomes. The copied DNA from each chromosome is arranged into two identical structures, called sister chromatids, which are attached to one another during the early stages of cell division. The sets of chromosomes align within the cell, with each chromatid attached to a structure called a spindle microtubule; when all chromatids are correctly attached, the spindle microtubule pulls the two halves of the chromatid pair to opposite sides of the cell. The cell then divides in two such that each new cell contains one complete set of chromosomes.

Cells have a mechanism, called the spindle assembly checkpoint, that delays cell division until each sister chromatid is attached to a spindle microtubule. The TRIP13 protein appears to regulate this checkpoint, although the exact mechanism is unclear.

Source: MedlinePlus, National Library of Medicine. Source publication: 2023-05-04. Source review: 2017-06.

ClinGen reviews

We found no matching ClinGen review in the data used here. This does not rule out a link between the gene and a condition.

ClinVar records

These numbers show what has been submitted to ClinVar. They cannot tell you how likely you are to have a condition.

Submitted alleles: 418
Submissions for variants in or overlapping this gene: 514
Submissions explicitly reporting this gene: 338
Alleles reported pathogenic / likely pathogenic: 9
VariationIDs with uncertain significance: 112
VariationIDs with conflicting classifications: 2

The rows count different things: alleles, submissions or VariationIDs. Their categories can overlap, so do not add them together. Pathogenic/likely pathogenic counts exclude structural variants that merely overlap a gene. A dash in the source means “not reported,” not zero.

NCBI produces the gene-summary file each week using counts recorded at the start of the month. The numbers may differ from those on the live ClinVar website. Read the field definitions ↗

View this gene in ClinVar ↗

YOUR DNA FILE

Can your DNA file tell you about TRIP13?

From a DNA test kit (such as 23andMe, AncestryDNA or MyHeritage). These kits check a fixed list of about 600,000 to 700,000 positions across your whole genome. ClinVar lists 9 alleles in TRIP13 reported as pathogenic or likely pathogenic. A kit checks only some of these positions, and often none of them.

From whole genome sequencing (a VCF file). Sequencing reads most of your genome. Your file lists the places where your DNA differs from the reference genome. Some regions are hard to sequence, including parts of some genes that have near-identical copies elsewhere, and a VCF file does not record which positions were read well.

If a variant is not in your file, that does not mean you don’t have it.

What BioDecode checks

BioDecode compares every variant in your file with ClinVar, on your own computer. For each match, it shows the ClinVar classification, the review status and the condition it was reported for. Your file is not uploaded.

A ClinVar classification applies to one particular variant and the condition it was reported for. It does not tell you about other variants in TRIP13.

BioDecode cannot fill gaps in your test, diagnose a condition or replace clinical testing.

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