GENE REFERENCE / HGNC:15992

ZNF341

zinc finger protein 341

protein-coding gene20q11.22Gene information

What does this gene do?

The ZNF341 gene provides instructions for making a transcription factor, which is a protein that attaches (binds) to specific regions of DNA and helps control the activity of particular genes. The ZNF341 protein is thought to regulate the activity of the STAT1 and STAT3 genes, controlling production of the STAT1 and STAT3 proteins, respectively. Both proteins are involved in the immune system. They control pathways in cells that help fight foreign invaders such as viruses, bacteria, and fungi. The STAT3 protein, in particular, transmits signals for the maturation of immune system cells, especially T cells and B cells. STAT3 is also involved in normal development and maintenance of bones and other tissues.

Researchers suspect that the ZNF341 protein controls the activity of other genes, although they have not been identified.

Source: MedlinePlus, National Library of Medicine. Source publication: 2020-08-18. Source review: 2019-08.

ClinGen reviews

ClinGen reviews the evidence linking a particular gene to a condition. Each rating below describes the strength of that link. It does not classify a variant in your DNA file.

Condition	Inheritance	Evidence
hyper-IgE recurrent infection syndrome 3, autosomal recessiveMONDO:0032654 · Evaluated 2024-06-04	Autosomal recessive	DefinitiveSCID-CID Gene Curation Expert Panel

ClinVar records

These numbers show what has been submitted to ClinVar. They cannot tell you how likely you are to have a condition.

Submitted alleles: 763
Submissions for variants in or overlapping this gene: 1,033
Submissions explicitly reporting this gene: 1,000
Alleles reported pathogenic / likely pathogenic: 35
VariationIDs with uncertain significance: 324
VariationIDs with conflicting classifications: 10

The rows count different things: alleles, submissions or VariationIDs. Their categories can overlap, so do not add them together. Pathogenic/likely pathogenic counts exclude structural variants that merely overlap a gene. A dash in the source means “not reported,” not zero.

NCBI produces the gene-summary file each week using counts recorded at the start of the month. The numbers may differ from those on the live ClinVar website. Read the field definitions ↗

View this gene in ClinVar ↗

YOUR DNA FILE

Can your DNA file tell you about ZNF341?

From a DNA test kit (such as 23andMe, AncestryDNA or MyHeritage). These kits check a fixed list of about 600,000 to 700,000 positions across your whole genome. ClinVar lists 35 alleles in ZNF341 reported as pathogenic or likely pathogenic. A kit checks only some of these positions, and often none of them.

From whole genome sequencing (a VCF file). Sequencing reads most of your genome. Your file lists the places where your DNA differs from the reference genome. Some regions are hard to sequence, including parts of some genes that have near-identical copies elsewhere, and a VCF file does not record which positions were read well.

If a variant is not in your file, that does not mean you don’t have it.

What BioDecode checks

BioDecode compares every variant in your file with ClinVar, on your own computer. For each match, it shows the ClinVar classification, the review status and the condition it was reported for. Your file is not uploaded.

A ClinVar classification applies to one particular variant and the condition it was reported for. It does not tell you about other variants in ZNF341.

BioDecode cannot fill gaps in your test, diagnose a condition or replace clinical testing.

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