CONDITION REFERENCE
Benign essential blepharospasm
Information from MedlinePlus Genetics about this condition and how it can be inherited.
About this condition
Benign essential blepharospasm is a condition characterized by abnormal blinking or spasms of the eyelids. This condition is a type of dystonia, which is a group of movement disorders that involve uncontrolled tensing of the muscles (muscle contractions), rhythmic shaking (tremors), and other involuntary movements. Benign essential blepharospasm is different from the common and temporary eyelid twitching that can be caused by fatigue, stress, or caffeine.
The signs and symptoms of benign essential blepharospasm usually appear in mid- to late adulthood and gradually worsen. The first signs and symptoms of the condition include an increased frequency of blinking; dry eyes; and eye irritation that is aggravated by wind, air pollution, sunlight, and other irritants. These signs and symptoms may begin in one eye, but they ultimately affect both eyes. As the condition progresses, spasms in the muscles that surround the eyes cause involuntary blinking or squinting. Over time, affected individuals find it increasingly difficult to keep their eyes open, which can severely impair their vision.
In some people with benign essential blepharospasm, the symptoms of dystonia spread beyond the eyes to affect other facial muscles. When people with benign essential blepharospasm also experience involuntary muscle spasms that affect the tongue and jaw (oromandibular dystonia), the combination of signs and symptoms is known as Meige syndrome.
Inheritance
- Autosomal dominant
A condition can have several forms with different inheritance patterns. Each pattern may apply to a different gene or form of the condition.
Related genes
MedlinePlus lists these genes for this condition. Open a gene page to read any available ClinGen reviews and ClinVar records.
YOUR DNA FILE
What can your DNA file tell you?
Your DNA file only includes the positions your test checked and reported. Consumer DNA kits usually test selected positions. Sequencing files can also leave out positions that were not reported or where the test could not give a result.
A variant missing from your file does not mean you tested negative for it. A ClinVar classification applies to a particular variant and the condition or finding it was reported for. It does not apply to everyone with that gene. An uncertain finding cannot establish a diagnosis.
BioDecode reads supported DNA files on your computer. It cannot fill gaps in your test, diagnose a condition or replace clinical testing.
Sources and dates
The source information on this page last changed on 2026-09-18.
MedlinePlus Source details
Source release: Fri, 18 Sep 2026 05:17:13 GMT
Source publication: 2024-11-21
Source review: 2024-11
SHA-256: fdc8bd614310c12718379cef6569962e5d0e791cecabcc355b53a72816ac263a
About the library sources · Latest validated release · Record 957d0850c7c7